Department of Physical Therapy
2500 California Plaza
Omaha, NE 68178
Prion diseases are a class of fatal neurodegenerative diseases that result in characteristic neuropathological changes in multiple brain and brainstem areas. There is no effective diagnostic test and there is no treatment for these diseases. A prion-infected animal or human will present with a wide variety of behavioral deficits including dementia, weakness, incoordination, tremor and sensory dysfunction late in the course of the disease. By the time the clinical signs of the prion disease are observed, the distribution of the prions, and the corresponding pathology, in the nervous system is widespread. Therefore, by the time disease is suspected, irreparable damage has been done to the nervous system. Because of the long incubation period it has been difficult to study behavioral and cellular changes that occur early after infection.
My research interests are directed towards identifying and mapping natural routes for prion entry into the central nervous system and determining how the agent spreads within the nervous system. By determining the temporal and spatial parameters of agent movement in the early stages of infection we can begin to identify the mechanism(s) responsible for the spread of prions in the nervous system. This includes identifying how the agent enters cells, how it moves within cells, and how it moves between cells. In addition, we can identify infected cells early after inoculation of certain peripheral tissues and begin to determine the mechanism whereby prions kill neurons.
Shara, M.A., Kincaid, A.E., Limpach, A.L., Sandstrom, R., Barrett, L., Norton, N., Bramble, J.D., Yasmin, T., Tran, J., Chatterjee, A., Bagchi, M. and Bagchi, D. (2007) Long-term safety evaluation of a novel oxygen-coordinated niacin-bound chromium (III) complex. Journal of Inorganic Biochemistry, 101(7): 1059-1069.
**Kincaid, A.E. and Bartz, J.C. (2007) The nasal cavity is a route for prion infection in hamsters. Journal of Virology, 81(9): 4482-4491.
Bartz, J.C., Kramer, M.L., Sheehan, M.H., Hutter, J.A.L., Ayers, J.I., Bessen, R.A. and Kincaid, A.E. (2007) Prion interference is due to a reduction in strain-specific PrPsc levels. Journal of Virology, 81(2): 689-697.
Shara, M., Yasmin, T., Kincaid, A.E., Limpach, A.L., Bartz, J.C., Brenneman, K.A., Chatterjee, A., Bagchi, M., Stohs, S.J. and Bagchi, D. (2005) Safety and Toxicological Evaluation of a Novel Niacin-Bound Chromium (III) Complex. Journal of Inorganic Biochemistry, 99(11): 2161-2183.
Marsh, R.F., Kincaid, A.E., Bessen, R.A. and Bartz, J.C., (2005) Interspecies transmission of chronic wasting disease to squirrel monkeys (Saimiri sciureus). Journal of Virology, 79(21): 13794-13796.
**Bartz, J.C., Dejoia, C., Tucker, T., Kincaid, A.E., and Bessen, R.A. (2005) extraneural prion neuroinvasion without lymphoreticular system infection. Journal of Virology, 79(18): 11858-11863.
Robinson, B.S. and Kincaid, A.E. (2004) Effects of repetitive motion on the perception of tactile sensation in the fingers of musicians. Perceptual and Motor Skills, 99: 1171-1183.
Mulcahy, E.R., Bartz, J.C., Kincaid, A.E. and Bessen, R.A. (2004) Prion infection of skeletal muscle cells and papillae in the tongue. Journal of Virology, 78(13): 6792-6798.
Bartz, J.C., Kincaid, A.E. and Bessen, R.A. (2003) Rapid prion neuroinvasion following tongue infection. Journal of Virology, 77(11): 583-591.
Kincaid, A.E., Duncan, S. and Scott, S.A. (2002) Comparison of fine motor abilities in musicians and nonmusicians: differences in timing versus sequence accuracy in a simple bimanual fingering pattern. Perceptual and Motor Skills, 95: 245-257.
Bartz, J.C., Kincaid, A.E. and Bessen, R.A. (2002) Retrograde transport of transmissible mink encephalopathy within descending motor spinal tracts. Journal of Virology, 76(11): 5759-5768.
**This manuscript was a "Spotlight" publication in the Journal of Virology and was featured as a select publication in ASM Microbe.
California State University, Long Beach---Physical Therapy
University of Michigan,
Ann Arbor---Anatomy and
Thesis Title: "Novel connections and dopaminergic regulation of globus pallidus neurons in the rat"
Advisors: Anne B. Young, M.D., Ph.D. and Sarah W. Newman, Ph.D.
1985-1988 Rackham Regents' Fellow, University of Michigan
1988-1991 Graduate Research Assistant in lab of Anne B. Young, M.D., Ph.D., Department of Neurology, University of Michigan
1991-1995 Research Associate in lab of Charles J. Wilson, Ph.D., Department of Anatomy and Neurobiology, University of Tennessee Medical School
1995-2002 Assistant Professor, Creighton University. Primary appointment in department of Physical Therapy, with secondary appointments in Biomedical Science and Pharmaceutical Sciences
2003-present Associate Professor, Creighton University. Primary appointment in department of Physical Therapy, with secondary appointments in Biomedical Science and Pharmaceutical Sciences
1997 Health Futures Foundation Faculty Development Award, Creighton University
2000 Robert F. Kennedy Award for Outstanding Teaching, Creighton University Student Union
2000 Excellence in Teaching Award, Creighton University School of Pharmacy and Health Professions Faculty