Current Research

Our research program addresses pathogenic and therapeutic questions of some the most devastating viral and neuroimmune disorders facing the global community including molecular, epidemiological, and biochemical approaches to address fundamental questions concerning viral replication, latency, assembly and pathogenesis. These projects include the investigation of mechanisms of HIV replication and pathogenesis; and neurodegenerative diseases such as Alzheimer's disease, prion diseases and HIV-1-associated dementia. Other projects involve chronic and latent infections caused by viruses such as herpes simplex, Epstein-Barr and Kaposi's Sarcoma associated herpesvirus. Investigators are also studying viral host interactions including the mechanism of viral induced cellular transformation

Current Research

RESEARCH PROJECTS

» Herpesvirus Anisa Kaenjak Angeletti, PhD
» Mechanisms that control stable replication of human papillomaviruses (HPVs) Peter C. Angeletti, PhD
» Prion Targeting Jason C. Bartz, PhD
» Development of cytolytic CD4 T cell responses through vaccination or viral infection Deborah M. Brown, Ph.D.
» Protein Structure and Function, Proteomics Pawel Ciborowski, PhD

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HIV Neuropathogenesis

Howard Gendelman, MD

» Evaluating different immunization strategies using adjuvants and antibody immunotherapies to enhance protective immune responses induced by HIV vaccine candidates. Santhi Gorantla, PhD
» Understand how alpha-herpesviruses establish, maintain, and reactivate from latency in sensory neurons Clinton Jones, PhD
» Prion Entry into the Nervous System Anthony E. Kincaid, PhD
» The Antiviral Role of RNA Interference in Mammals T. Jack Morris, PhD
» RNA Virus Gene Expression Asit K. Pattnaik, PhD
» IL-12 expression during innate anti-viral immunity against Theiler's Virus infection Thomas M. Petro, PhD
» Murine model of HIV-1encephalitis in NOD/SCID mice reconstituted with human lymphocytes Larisa Poluektova, MD, PhD

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Chlorella Viruses Biology

James Van Etten, PhD

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HIV and Herpes Virus Pathogenesis

Charles Wood, PhD

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HIV Neurophysiology

Huangui Xiong, MD, PhD

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Herpes Viral Latency and Interferon Regulatory Factors

Luwen Zhang, PhD

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Chemokines and HIV Dementia

Jialin Zheng, MD