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Alan Russell Doster
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Professor
Department of Veterinary and Biomedical Sciences
137 Veterinary Diagnostic Center
University of Nebraska-Lincoln
Lincoln, NE 68583-0907
Phone - (402) 472-1434
Fax - (402) 472-3094
adoster@unl.edu |
Publication and Research Interests
My primary research focus has
been on the pathogenesis of various infectious organisms in domestic
species. Currently, research is concentrated on the pathogenesis
of porcine respiratory and reproductive syndrome virus (PRRSV)
in swine and latency infection of infectious bovine rhinotracheitis
virus in cattle. Research has lead to development of a genetically
engineered field virus to produce a commercially available vaccine
that is efficacious against viral challenge with homologous and
heterologous strains of PRRSV in swine. Current efforts deal
with the latency and persistence of PRRSV infection in individual
pigs and degree of resistance to PRRSV infection in off-spring
incurred by use of specific genetically resistant breeding stock.
Recent Publications
Sur JH, Doster AR, Osorio FA: Apoptosis induced in vivo during
acute infection by porcine reproductive and respiratory syndrome
virus. Veterinary Pathology 35:506-514, 1998.
Jiang Y, Hossain A, Winkler MT, Holt T, Doster A, Jones C: A protein
encoded by the latency-related gene of bovine herpesvirus 1 is
expressed in trigeminal ganglionic neurons of latently infected
cattle and interacts with cyclin-dependent kinase 2 during productive
infection. Journal of Virology 7 2(10):8133-1842, 1998.
Allende R., Lewis TL, Lu Z, Rock DL, Kutish GF, Ali A, Doster
AR, Osorio FA: North American and European porcine reproductive
and respiratory syndrome viruses differ in non-structural protein
coding regions. Journal of General Virology 80:307-315, 1999.
Kwang J., S. Yang, F.A. Osorio, S. Christian, J. Galeota Wheeler,
K.M. Lager, S. Low, L. Chang, A.R. Doster, A. White, C.C. Wu: Characterization
of antibody response to porcine reproductive and respiratory syndrome
virus ORF5 product following infection and evaluation of its diagnostic
use in pigs. Journal of Veterinary Diagnostic Investigation 11:391-395,
1999.
Winkler MTC, Doster A, Jones C: Bovine herpesvirus 1 can infect
CD4+ T lymphocytes and induce programmed cell death during acute
infection of cattle. Journal of Virology 73:8657-8668, 1999.
Winkler MTC, Doster A, Jones C: Persistence and reactivation of
bovine herpesvirus 1 in the tonsils of latently infected calves.
Journal of Virology 74:5337-5346, 2000.
Jones C. Newby TJ, Holt T, Doster A, Stone M, Ciacci-Zanella J,
Webster CJ, Jackwood MW: Analysis of latency in cattle after inoculation
with a temperature sensitive mutant of bovine herpesvirus 1 (RLB106).
Vaccine. 18(27):3185-95, 2000.
Allende R, Kutish GF, Laegreid W, Lu Z, Lewis TL, Rock DL, Friesen
J, Galeota JA, Doster AR, Osorio FA: Mutations in the genome of
porcine reproductive and respiratory syndrome virus responsible
for the attenuation phenotype. Archives of Virology 145:1149-1161,
2000.
Winkler MT, Schang L, Doster A, Holt T, Jones C: Analysis of cyclins
in trigeminal ganglia of calves infected with bovine herpesvirus-1.
Journal of General Virology 81: 1-6, 2000.
Sur JH, Doster AR, Galeota JA, Osorio FA: Evidence of localization
of porcine reproductive and respiratory syndrome virus (PRRSV)
antigen and RNA in ovarian follicles in gilts. Veterinary Pathology
38(1):58-66, 2001.
Osorio F, J.A. Galeota , E. Nelson , B. Brodersen, A. Doster,
R. Wills R, F. Zuckermann, W.W Laegreid. Passive transfer of virus
specific antibodies confers protection against reproductive failure
induced by a virulent strain of porcine reproductive and respiratory
syndrome virus and establishes sterilizing immunity. Virology 302(1):9-20,
2002.
Inman M., Lovato L., Doster A., Jones C. A mutation in the latency-related
gene of bovine herpesvirus 1 reduces establishment and reactivation
of latency in calves. Journal of Virology 76(13):6771-6779, 2002.
Winkler M.T.C., A.R Doster, J.H. Sur, C. Jones. 2002. Analysis
of bovine trigeminal ganglia following infection with bovine herpesvirus
I. Veterinary Microbiology 86(1-2):139-155), 2002.
Wills R.W., Doster A.R., Osorio F.A.: Transmission of porcine
reproductive and respiratory syndrome virus (PRRSV) to age-matched
sentinel pigs. Journal of Swine Health and Production 10(4):161-165,
2002.
Wills RW, Doster AR, Galeota J, Sur JH, Osorio FA. Duration of
infection and proportion of pigs infected with porcine reproductive
and respiratory syndrome virus (PRRSV). Jour Clin Microbiol 41(1):58-62,
2003.
Lovato L, Inman M, Hendersen G, Doster A, Jones C. Infection of
cattle with a bovine herpesvirus 1 strain that contains a mutation
in the latency-related gene leads to increased apoptosis in trigeminal
ganglia during the transition from acute infection to latency.
Jour Virol 77(8):4848-57, 2003.
Sur J.H., R. Allende, A.R. Doster. 2003. Vesicular stomatitis
virus infection and neuropathogenesis in the murine model are associated
with apoptosis. Vet Pathol 40:512-520, 2003.
Bastos R.G., A.O. Dellagostin, R.G. Barletta, A.R. Doster, E.
Nelson, F. Zuckermann, Osorio F.A. Immune response of pigs inoculated
with Mycobacterium bovis BCG expressing a truncated form of GP5
and M protein of porcine reproductive and respiratory syndrome
virus. Vaccine 22:467-474, 2004.
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