|
|
Tsuneya Ikezu, MD, PhD
Research Interests:
Our research focuses on the molecular pathogenesis of
Alzheimer's disease (AD) and HIV-associated dementia (HAD). The
hypothesis being tested here is that chronic brain inflammatory
reactions contribute to the progressive neurodegeneration often
observed during AD. Such an idea is substantiated by a recent
report that anti-inflammatory drugs slow the onset and progression
of disease, including A b deposition.
Neuron-microglial interaction is being studied in both animal
models and primary culture systems.
Our laboratory is also involved in the molecular characterization
of mononuclear phagocyte activation upon HIV-1 infection. We
have recently characterized a novel transcriptional factor, OTK18,
which is expressed in human macrophage upon HIV-1 infection and
has anti-retroviral activity in vitro. We are investigating the
molecular mechanism of the anti-retroviral effect of OTK18 as
a transcriptional factor. These studies will lead to extension
of our understanding of HIV-1 associated dementia and AD. Multiple
experimental methods, including molecular biology, neurobiology,
and immunology, are utilized for the investigation.
Select Publications (last 3 years):
- Yamamoto M, Horiba M, Buescher JL, Huang DR, Gendelman
HE, Ransohoff RM, and Ikezu T. Overexpression of monocyte chemotactic
protein-1 (MCP)-1/CCL2 in _-amyloid precursor protein transgenic
mice show accelerated diffuse b-amyloid deposition. Am J Pathol,
in press (2005)
- Carlson KA, Leisman G, Limoges J, Pohlman GD, Horiba M,
Buescher JL, Gendelman HE, and Ikezu T. Molecular characterization
of a novel anti-retroviral transcriptional factor, OTK18. J Immunol
172:381-391 (2004)
- Carlson KA, Limoges J, Pohlman GD, Masliah E, Ikezu T, and
Gendelman HE. OTK18: A novel macrophage transcriptional suppressive
factor linked to HIV encephalitis. J Neuroimmunol, 150:186-198
(2004)
- Xiong H, McCabe L, Castello JK, Anderson ER, Weber GA, Monagham
D, and Ikezu T. Activation of NR1a/NR2B receptors by macrophage
conditioned media stimulated with APP-processing products:
Implications for Alzheimer’s disease. Neurobiol Aging 25:905-911
(2004)
- Li X, Ikezu T, and Hexum TD. G Protein bg Subunits Mediate
the NPY Enhancement of ATP-Stimulated InsP Formation in Bovine
Chromaffin Cells. PEPTIDES 25:267-74 (2004)
- Ikezu T, Luo X, Weber GA, Zhao J, McCabe L, Buescher JL,
Ghorpade A, Zheng J, and Xiong H. Amyloid precursor protein-processing
products affects mononuclear phagocytes activation: Differential
function of sAPP and A_ for neurotoxicity. J Neurochem 85:925-934
(2003)
- Luo X, Weber GA, Zheng J, Gendelman HE, and Ikezu T. C1q-calreticulin
induced oxidative neurotoxicity: Relevance for the neuropathgenesis
of Alzheimer’s disease. J Neuroimmunol, 135:62-71 (2003)
- Li X, Zhang P, Drakulich DA, Shen M, Weber GA, Ikezu T,
and Hexum TD. Infection of Bovine Adrenal Chromaffin Cells Using
a Recombinant Adenovirus Expressing GFP. J Neurosci Methods 122:91-96
(2002)
|
