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Georgette D. Kanmogne, Ph.D. MPH
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Assistant Professor
Department of Pharmacology and Experimental Neuroscience
Senior Scientist / Center for Neurovirology and Neurodegenerative
Disorders
University of Nebraska Medical Center
Omaha NE 68198-5215
Tel: 402-559-4084
Fax: 402-559-8922
Email: gkanmogne@unmc.edu |
Research Goals:
- Vascular Biology of HIV infection.
- Mechanisms of HIV-mediated Blood-brain
barrier dysfunction and HIV invasion of the brain.
- Mechanisms of
HIV-mediated lung injury and AIDS pulmonary complications
Techniques
- Tissue culture, ELISA
- Immunohistochemistry
- Laser Confocal Microscopy
- Cell Migration Assays
- Southern & Western blot analysis
- Autoradiography
- Microarray & proteomics
- PCR, RT-PCR, Real -Time PCR
In vivo studies
- Development an animal model (Hu PBL-NOD/SCID mice)
for HIV-1 Lymphocytic Alveolitis
Selected publications
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Kanmogne, G.D., Primeaux, C and Grammas, P.
(2005). Induction of apoptosis and endothelin-1 secretion in primary
human lung endothelial cells by HIV-1 gp120 proteins. Biochem Biophys
Res Commun 333: 1107-1115
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Kanmogne, G.D., Primeaux, C and Grammas, P.
(2005). HV-1 gp120 proteins alter tight junction protein expression
and brain endothelial cell permeability: Implications for the pathogenesis
of HIV-associated dementia. J. Neuropathol. Exp. Neurol. 64 (6),
498-505
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Kanmogne, G.D. (2005) Noninfectious pulmonary
complications of HIV/AIDS. Curr Opin Pulm Med 11, 208-212.
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Kanmogne, G.D., Kennedy, R.C and Grammas, P.
(2003). Is HIV involved in the pathogenesis of non-infectious pulmonary
complications in infected patients? Current HIV Research 1(3),
385-393.
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Kanmogne, G.D., Kennedy, R.C and Grammas, P.
(2002). HIV-1 gp120 proteins and gp160 peptides are toxic to brain
endothelial cells and neurons: possible pathway for HIV entry into
the brain and HIV-associated dementia. Journal of Neuropathology
and Experimental Neurology 61(11), 992-1000.
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Kanmogne, G.D., Kennedy, R.C, and Grammas, P.
(2002). Infection of baboon microglia with SIV/HIV recombinant
viruses: role of CD4 and chemokine receptors. AIDS Research
and Human Retroviruses 18 (8), 557-565.
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Kanmogne, G.D., Kennedy, R.C, and Grammas, P.
(2001) Analysis of human lung endothelial cells for susceptibility
to HIV Type 1 infection, coreceptor expression, and cytotoxicity
of gp120 protein. AIDS Research and Human Retroviruses 17 (1),
45-53.
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Kanmogne, G.D., Grammas, P. and Kennedy, R.C.
(2000). Analysis of human endothelial cells and cortical neurons
for susceptibility to HIV-1 infection and coreceptor expression. Journal
of Neurovirology 6, 519-528.
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Sarkodie, Y.A., Sangare,
K.A., D’Almeida, O.A. and Kanmogne,
G.D. (1998) Distribution of CD4+ cell levels
in patients with clinical AIDS, but without HIV antibodies
in 3 West-African countries. Journal of Clinical Virology 11,
173-181.
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Kanmogne, G., A. Sangare, O. d’Almeida,
Y. Adu-Sarkodie, F. Davies, H. Lee and J-P Allain. (1998)
Human T-cell leukaemia/lymphoma virus type I infection in West
African patients with clinical AIDS. AIDS 12 (16),
223.
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