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University of Nebraska–Lincoln

Nebraska Center for Virology

The Strength of Cooperation Among Three Institutions

James Van Etten, PhD

William Allington Distinguished Professor of Plant Pathology
University of Nebraska-Lincoln
Department of Plant Pathology
406 Plant Sciences Hall
Lincoln, NE 68583-0722
Phone - 402.472.3168
Fax - 402.472.2853
jvanetten@unlnotes.unl.edu

Lab

Publications and Research Interests:

From 1964 to present: 181 research papers and 33 review articles. Of the research papers, 14 deal with the isolation and characterization of the unusual bacteriophage phi 6 and 121 papers deal with the isolation and characterization of chlorella viruses. The majority of the remaining papers are on the physiology and biochemistry of fungal development. All of my current research efforts are on viruses of eukaryotic algae.

Selected Recent Publications:

1. Neupartl, M., C. Meyer, I. Woll, F. Frohns, M. Kang, J.L. Van Etten, D. Kramer, B. Hertel, A. Moroni, and G. Thiel. (2008). Chlorella viruses evoke a rapid release of K+ from host cells during early phase of infection. Virology 372, 340-348.

2. Balss, J., P. Papatheodorou, M. Mehmel, D. Baumeister, B. Hertel, N. Delaroque, F.C. Chatelain, D.L. Minor, J.L. Van Etten, J. Rassow, A. Moroni, and G. Thiel. (2008). Transmembrane domain length of viral K+ channels is a signal for mitochondria targeting. Proc. Natl. Acad. Sci. USA (in press).

3. Mujtaba, S., K.L. Manzur, J.R. Gurnon, M. Kang, J.L. Van Etten, and M-M. Zhou. (2008). Epigenetic transcription repression of cellular genes by a viral SET protein. Nature Cell Biol. (in press).

4. Van Etten, J.L. Viruses that infect protists. Chapter 19 in "Fields Virology, fifth edition". (D.M. Knipe and P.M. Howley, ed.) pp. 627-640, Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, 2007.

5. Fruscione, F., L. Sturla, G. Duncan, J.L. Van Etten, P. Valbuzzi, A. De Flora, E. Di Zanni, and M. Tonetti. (2008). Differential role of NADP+ and NADPH in the activity and structure of GDP-D-mannose 4,6-dehydratase from two chlorella viruses. J. Biol. Chem. 283, 184-193.

6. Zhang, Y., Y. Xiang, J.L. Van Etten, and M.G. Rossmann. Structure and function of a chlorella virus PBCV-1 encoded glycosyltransferase. Structure 15, 1-9, 2007.

7. Zhang, Y., F. Maley, G.F. Maley, G. Duncan, D.D. Dunigan, and J.L. Van Etten. Chloroviruses encode a bifunctional dCMP-dCTP deaminase that produces two key intermediates in dTTP formation. J. Virol. 81, 7662-7671, 2007.

8. Fitzgerald, L.A., M.V. Graves, X. Li, J. Hartican, A.J.P. Pfitzner, E. Hoffart, and J.L. Van Etten. Sequence and annotation of the 288-kb ATCV-1 virus that infects an endosymbiotic chlorella strain of the heliozoon Acanthocystis turfaceaVirology 362, 350-361, 2007.  [Cover photo]

9. Baumann, S., A. Sander, J.R. Gurnon, G.M. Yanai-Balser, J.L. Van Etten, and M. Piotrowski. Chlorella viruses contain genes encoding a complete polyamine biosynthetic pathway.  Virology 360,209-217, 2007.

10. Fitzgerald, L.A., M.V. Graves, X. Li, T. Feldblyum, W.C. Nierman, and J.L. Van Etten. Sequence and annotation of the 369-kb NY-2A and the 345-kb AR158 viruses that infect Chlorella NC64A. Virology 358, 472-484, 2007.

11. Yamada, T., H. Onimatsu, and J.L. Van Etten. Chlorella viruses. In: Adv. in    Virus  Res. (K. Maramorosch and A.J. Shatkin, eds). Elsevier Inc. 66, 293-336, 2006.

12. Agarkova, I.V., D.D. Dunigan, and J.L Van Etten. Virion-associated restriction
endonucleases of chloroviruses.  J. Virol. 80, 8114-8123. [highlighted article] 2006.

Education:

Carleton College, Minnesota
BA, Biology
1960

University of Illinois, Urbana, IL
MS, Plant Pathology
1963

University of Illinois, Urbana, IL
PhD, Plant Pathology
1965

University of Pavia, Pavia, Italy
Postdoc, Molecular Biology
1965-66

Professional Experience:

NSF Postdoctoral Fellow, Department of Genetics
University of Pavia, Pavia, Italy, 1965-66

Assistant Professor, Plant Pathology
Univ. of Nebraska, Lincoln, NE, 1966-69

Associate Professor, Plant Pathology
University of Nebraska, Lincoln, NE 1969-74

Professor, Plant Pathology
University of Nebraska, Lincoln, NE, 1974-86

William Allington Professor of Plant Pathology, 1986-93

William Allington Distinguished Professor of Plant Pathology, 1993-present

Coordinator of the UNL Plant Science Initiative, 1997-99

Co-Director of the Nebraska Center for Virology, 2000-present

Membership on Editorial Boards and Government Panels: Editorial Board, Phytopathology, 1974-77

Associate Editor, Experimental Mycology, 1976-96

Editorial Board, Journal of Bacteriology, 1980-85

Editorial Board, Molecular and Cellular Biology, 1981-85

Associate Editor, Virology, 1989-present

Editorial Board, Molecular Plant Pathology, 1999-present

Co-chairman of Gordon Conference on Fungal Metabolism, 1984

Committee member of NIH study section on Microbial Physiology, 1978, 1981, 1984-87

Committee member of the USDA Grants (Plant Pathology/Weeds) Panel, 1991, 1992

Honors and Professional Affiliations:

Fellow of the American Phytopathological Society, August 1989

Recipient of the University of Nebraska Outstanding Research and Creative Activity Award, 1992

Fellow of the American Association for the Advancement of Science, 1993

Recipient of the Nebraska Sigma Xi outstanding scientist award, 1999

Fellow of the American Academy of Microbiology, 2001

Elected member of the National Academy of Sciences, 2003