Georgette D. Kanmogne, Ph.D. MPH

Associate Professor
Vice Chair for Resource Allocation and Faculty Development
Department of Pharmacology and Experimental Neuroscience
University of Nebraska Medical Center
Omaha NE 68198-5215
Tel: 402-559-4084
Fax: 402-559-8922
Email: gkanmogne@unmc.edu

Research Articles

  • Vascular Biology of HIV infection.
  • Mechanisms of HIV-mediated Blood-brain barrier dysfunction and HIV invasion of the brain.
  • Mechanisms of HIV-mediated lung injury and AIDS pulmonary complications

Techniques

  • Tissue culture, ELISA
  • Immunohistochemistry
  • Laser Confocal Microscopy
  • Cell Migration Assays
  • Southern & Western blot analysis
  • Autoradiography
  • Microarray & proteomics
  • PCR, RT-PCR, Real -Time PCR

In vivo studies

  • Development an animal model (Hu PBL-NOD/SCID mice) for HIV-1 Lymphocytic Alveolitis

Selected publications

  1. Kanmogne, G.D., Primeaux, C and Grammas, P. (2005). Induction of apoptosis and endothelin-1 secretion in primary human lung endothelial cells by HIV-1 gp120 proteins. Biochem Biophys Res Commun 333: 1107-1115

  2. Kanmogne, G.D., Primeaux, C and Grammas, P. (2005). HV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: Implications for the pathogenesis of HIV-associated dementia. J. Neuropathol. Exp. Neurol. 64 (6), 498-505

  3. Kanmogne, G.D. (2005) Noninfectious pulmonary complications of HIV/AIDS. Curr Opin Pulm Med 11, 208-212.

  4. Kanmogne, G.D., Kennedy, R.C and Grammas, P. (2003). Is HIV involved in the pathogenesis of non-infectious pulmonary complications in infected patients? Current HIV Research 1(3), 385-393.

  5. Kanmogne, G.D., Kennedy, R.C and Grammas, P. (2002). HIV-1 gp120 proteins and gp160 peptides are toxic to brain endothelial cells and neurons: possible pathway for HIV entry into the brain and HIV-associated dementia. Journal of Neuropathology and Experimental Neurology 61(11), 992-1000.

  6. Kanmogne, G.D., Kennedy, R.C, and Grammas, P. (2002). Infection of baboon microglia with SIV/HIV recombinant viruses: role of CD4 and chemokine receptors. AIDS Research and Human Retroviruses 18 (8), 557-565.

  7. Kanmogne, G.D., Kennedy, R.C, and Grammas, P. (2001) Analysis of human lung endothelial cells for susceptibility to HIV Type 1 infection, coreceptor expression, and cytotoxicity of gp120 protein. AIDS Research and Human Retroviruses 17 (1), 45-53.

  8. Kanmogne, G.D., Grammas, P. and Kennedy, R.C. (2000). Analysis of human endothelial cells and cortical neurons for susceptibility to HIV-1 infection and coreceptor expression. Journal of Neurovirology 6, 519-528.

  9. Sarkodie, Y.A., Sangare, K.A., D'Almeida, O.A. and Kanmogne, G.D. (1998) Distribution of CD4+ cell levels in patients with clinical AIDS, but without HIV antibodies in 3 West-African countries. Journal of Clinical Virology 11, 173-181.

  10. Kanmogne, G., A. Sangare, O. d'Almeida, Y. Adu-Sarkodie, F. Davies, H. Lee and J-P Allain. (1998) Human T-cell leukaemia/lymphoma virus type I infection in West African patients with clinical AIDS. AIDS 12 (16), 223.

Education

MPH in Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center.
2002

Ph.D. in Molecular Parasitology, University of Bristol, UK.
1992 - 1996

D.E.A. (Master in Science) in Biochemistry, University of Yaounde, Cameroon.
1988 - 1989

Maîtrise in Biochemistry, University of Yaounde, Cameroon.
1987 - 1988

Licence (Bachelor of Science) in Zoology, University of Yaounde, Cameroon.
1984 - 1987

Professional Positions

Jan 2005 - Assistant Professor, Department of Pharmacology, and Experimental Neuroscience; Senior Scientists, Center for Neurovirology & Neurodegenerative Disorders. University of Nebraska Medical Center. Research interest: neuroscience and vascular biology of HIV infection.

July 2002 – Dec 2004 Research Assistant Professor, Department of Pathology, University of Oklahoma Health Sciences Center. Research interest: neuroscience and vascular biology of HIV infection.

June 1998 – June 2002 Postdoctoral Research Associate, University of Oklahoma Health Sciences Center, Department of Pathology. Research interests: Neuropathogenesis of HIV infection and HIV-associated dementia.

July 1996 - May 1998 Postdoctoral Fellow, Department of Haematology, University of Cambridge, UK. Research interests: molecular characterization of HIV variants and subtypes.

Oct 1990 - June 1992 Laboratory Instructor to undergraduate students (biochemistry major). University of Yaounde, Cameroon.

Fellowships & Awards :

Feb.1992 - June 1996 World Health Organization (WHO) Research Training Grant.

May 1995 Travel Award from the University of Bristol Alumni Foundation.

July 1995 Travel Award from the British Society of Parasitology (BSP).

April 2000 Post-doctoral travel award from the American Society for Virology

Sept, 2000 Travel Award from the Oklahoma Center for Neuroscience.

Jul. 2001 Post-doctoral Research Award from the American Foundation for AIDS Research

Oct. 2003 Pfizer Atorvastatin Research Award

Jul. 2005 American Lung Association Career Investigator Award.