Murine model of HIV-1encephalitis in NOD/SCID mice reconstituted with human lymphocytes

Larisa Poluektova, MD, Ph.D. - University of Nebraska Medical Center - Center for Neurovirology and Neurodegenerative Disorders

We are using the murine model to investigate: 1) earlier consequences of HIV-1 associated CNS disease; 2) mechanisms of local brain damage and repair;
2) humanized SCID mice as a test system for HIV-1 vaccine evaluation and screen potential vaccine candidates.