Peter C. Angeletti, PhD

Professor

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Dr. Angeletti’s work is focused on the replication and pathogenesis of human papillomaviruses (HPVs). His recent collaborative studies investigate the role of multi-HPV genotype infections on cervical dysplasia in HIV-positive Tanzanian women. In further studies, Dr. Angeletti’s lab discovered that certain bacterial families within the cervical microbiome (such as Mycoplasma), are associated with high-grade cervical dysplasia. His team is now investigating chronic inflammation induced by microbial dysbiosis as a key trigger for the progression of cervical neoplasias. In another study, his lab is researching the cause of ocular surface squamous neoplasia (OSSN), which is the sixth most common cancer among HIV-positive Zambians. The goal of these studies is to determine whether DNA tumor viruses have a role in the initiation and progression of the aggressive forms of this disease.

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