Core Facilities
   - Flow Cytometry
   - Microscopy
   - Structural Protein

Student and Postgraduate Training Opportunities
   - Fogarty AITRP
   - NIH Fellowships
   - Graduate Programs
   - Undergraduate Summer
     Research Experience in
     Virology (USREV)

News & Job Postings

Affiliated Institutions

Contacts

Home

NCV LINKS
	U.S. Department of Health and Human Services - National Institutes of Health
	National Center for Research Resources

The Nebraska Center for Virology Research Program

Our research program addresses pathogenic and therapeutic questions of some the most devastating viral and neuroimmune disorders facing the global community including molecular, epidemiological, and biochemical approaches to address fundamental questions concerning viral replication, latency, assembly and pathogenesis. These projects include the investigation of mechanisms of HIV replication and pathogenesis; and neurodegenerative diseases such as Alzheimer's disease, prion diseases and HIV-1-associated dementia. Other projects involve chronic and latent infections caused by viruses such as herpes simplex, Epstein-Barr and Kaposi's Sarcoma associated herpesvirus. Investigators are also studying viral host interactions including the mechanism of viral induced cellular transformation.

RESEARCH PROJECTS
»	Herpesvirus	Anisa Kaenjak Angeletti, PhD
»	Mechanisms that control stable replication of human papillomaviruses (HPVs)	Peter C. Angeletti, PhD
»	Prion Targeting	Jason C. Bartz, PhD
»	Prion Neuroinvasion	Richard Bessen, PhD
»	Protein Structure and Function, Proteomics	Pawel Ciborowski, PhD
»	HIV Neuropathogenesis	Howard Gendelman, MD
»	Viral and cellular factors that regulate HSVE	Melissa (Stone) Inman, PhD
»	Herpesviruses Latency	Clinton Jones, PhD
»	Prion Entry into the Nervous System	Anthony E. Kincaid, PhD
»	Protein Nucleic Acid Interactions using FRET	Lawrence Parkhurst,PhD
»	RNA Virus Gene Expression	Asit K. Pattnaik, PhD
»	BBB Transport Systems in HIV-1 Infection	Yuri Persidsky, MD, PhD; Tsuneya Ikezu, MD, PhD
»	IL-12 expression during innate anti-viral immunity against Theiler’s Virus infection	Thomas M. Petro, PhD
»	Murine model of HIV-1encephalitis in NOD/SCID mice reconstituted with human lymphocytes	Larisa Poluektova, MD, PhD
»	Chlorella Viruses Biology	James Van Etten, PhD
»	Retroviruses Assembly	Robert Weldon, Jr., PhD
»	Retroviruses Pathogenesis and Fitness:Virus and Host Determinants	John West, PhD
»	HIV and Herpes Virus Pathogenesis	Charles Wood, PhD
»	HIV Neurophysiology	Huangui Xiong, MD, PhD
»	Herpes Viral Latency and Interferon Regulatory Factors	Luwen Zhang, PhD
»	Chemokines and HIV Dementia	Jialin Zheng, MD

NCV Research Close-Up

HIV and Herpes Virus Pathogenesis

Charles Wood, PhD - University of Nebraska-Lincoln, School of Biological Sciences.

The laboratory focuses on HIV and human herpesvirus, and the roles play by these viruses in immunosuppression and cancer development. One of the ongoing projects is to study the transmission and evolution of HIV and Human Herpesvirus 8 (HHV-8), a virus linked to Kaposi's Sarcoma, a rare cancer often found in AIDS patients. This project is being carried out in Africa where infection by both HIV and HHV-8 is at the epidemic level. Our goal is to understand how these viruses regulate gene expression, replicate, transmit and cause diseases. This will lead to knowledge that can help in the development of strategies to prevent infection and disease development.