Replication of Human Papillomaviruses

Peter C. Angeletti, PhD - School of Biological Sciences - University of Nebraska - Lincoln

My research is focused on understanding the mechanisms that control long-term replication of human papillomaviruses (HPVs), since this is an important aspect to their ability to induce cancers. The goals of this research are: (1) To investigate the role of viral factors in stable replication of HPV genomes. (2) To determine the contribution of cis-acting elements, independent of viral factors, to maintenance of HPV genomes. (3) To identify cellular components which contribute to stable HPV replication.