Prion Neuroinvasion

Richard A. Bessen, Ph.D - Creighton University, Department of Medical Microbiology & Immunology.

This project will examine the oral routes of prion neuroinvasion. We are investigating 1) the mechanism(s) of prion uptake, transport, and trafficking in neurons, and 2) alterations in neuronal morphology and physiology during prion axonal transport and infection of neurons.