Faculty - Donald Weeks

Donald P. Weeks

Maxcy Professor of Agriculture and Natural Resources - Department of Biochemistry

(402) 472-7917 | Email

Research Interests

Our laboratory is engaged in two exciting and challenging areas of research. One deals with elucidation of the genetic and molecular mechanisms involved in the ability of algal cells (Chlamydomonas reinhardtii) to enhance photosynthesis by increasing internal levels of CO2 to 60x the external levels of CO2 (i.e., a carbon concentrating mechanism). The second line of research focuses on the genetic engineering of crop plants for enhanced photosynthesis, disease resistance and herbicide resistance.

Recent Papers

Recent Publications

Knockdown of a Limiting-CO2-inducible Gene HLA3 Decreases Bicarbonate Transport and Photosynthesis Efficiency in Chlamydomonas reinhardtii. 2009 Deqiang D, Miller AR, Horken KM, Weeks DP, and Spalding MH Proc. Natl. Acad. Sci. USA 106:5990-95

Crystal structure of dicamba monooxygenase - A Rieske nonheme oxygenase that catalyzes oxidative demethylation. R. Dumitru, W. Z. Jiang, D. P. Weeks, and M. A. Wilson. 2009 Journal of Molecular Biology 392(2):498-510

The Small Ubiquitin-like Modifier (SUMO) and SUMO Conjugating System of Chlamydomonas reinhardtii. 2008 Y. Wang, I. Ladunga, A.R. Miller, K. M. Horken, T. Plucinak, D. P. Weeks, and C. P. Bailey. Genetics 179:177-92

Dicamba tolerance: Enlarging and preserving biotechnology-based weed management strategies 2007 M.R. Behrens, N. Mutlu, S. Chakraborty, R. Dumitru, W. Jiang, B.J. LaVallee, P.L. Herman, T.E. Clemente and D.P. Weeks. Science 316:1185-8

Herman PL, Behrens M, Chakraborty S, Chrastil BM, Barycki J, Weeks DP. A three-component dicamba O-demethylase from Pseudomonas maltophilia, strain DI-6: gene isolation, characterization, and heterologous expression. J Biol Chem. 2005 Jul 1;280(26):24759-67. Epub 2005 Apr 26. PMID: 15855162 [PubMed - in process]

Chakraborty S, Behrens M, Herman PL, Arendsen AF, Hagen WR, Carlson DL, Wang XZ, Weeks DP. A three-component dicamba O-demethylase from Pseudomonas maltophilia, strain DI-6: purification and characterization. Arch Biochem Biophys. 2005 May 1;437(1):20-8. PMID: 15820213

Novoselov SV, Rao M, Onoshko NV, Zhi H, Kryukov GV, Xiang Y, Weeks DP, Hatfield DL, Gladyshev VN. Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii. EMBO J. 2002 Jul 15;21(14):3681-93. PMID: 12110581

Kovar JL, Zhang J, Funke RP, Weeks DP. Molecular analysis of the acetolactate synthase gene of Chlamydomonas reinhardtii and development of a genetically engineered gene as a dominant selectable marker for genetic transformation. Plant J. 2002 Jan;29(1):109-17. PMID: 12060231

Xiang Y, Zhang J, Weeks DP. The Cia5 gene controls formation of the carbon concentrating mechanism in Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5341-6. Epub 2001 Apr 17. PMID: 11309511