Research in the Markham Lab is focused on understanding the organization of (sphingo) lipid metabolism and how metabolic components of this pathway can influence critical cell-fate decisions. In order to understand how metabolites are involved in metabolic and physiological life processes, one must be able to measure them. Based on this philosophy, the Lab employs the latest tools in biochemistry ‒ mass spectrometry‒ to measure many molecules involved in plant sphingolipid biochemistry. These include, but are not limited to, fatty acids, steroids, amino acids, sphingolipids, glycerolipids, nucleotide phosphates and UDP/GDP-sugars. By obtaining accurate measurements of these molecules in different genetic backgrounds, researchers are able to piece together how the different structures contribute to sphingolipid biochemistry, cellular signaling and plant physiology.