Chemokines and HIV Dementia

Jialin Zheng, MD - University of Nebraska Medical Center, Center for Neurovirology and Neurodegenerative Disorders.

The engagement of neuronal chemokine receptors by progeny HIV-1 and chemokines is investigated exploring its relevance in HIV-1 neuropathogenesis. The hypothesis proposed is that virion and/or chemokine binding to chemokine receptors induces activation of neuronal signaling pathways leading to cell injury and/or repairing.