Research Assistant Professor
Nebraska Center for Virology
School of Biological Sciences
University of Nebraska – Lincoln
4240 Fair Street, Morrison Center
Lincoln, NE 68583-0900
Phone: (402) 472-4575
Fax: (402) 472-3323
Email: labrahamyan2@unl.edu
Research Articles
| 1. | Guo H., Abrahamyan L.G., Liu C., Waltke M., Geng Y., Chen Q., Wood C., and X. Kong. Comparative analysis of the fusion efficiency elicited by Env V1-V5 regions derived from human immunodeficiency virus type 1 transmitted perinatally. J. Gen. Virol. 2012 Dec;93(Pt 12):2635-45. |
| 2. | Belzile J-P*., Abrahamyan L.G*., Gerard F.C.A., and E. Cohen. Formation of Mobile Chromatin-Associated Nuclear Foci Containing HIV-1 Vpr and VPRBP Is Critical for the Induction of G2 Cell Cycle Arrest. PLoS Pathogens. Sep 2;6(9), 2010. *Equal contribution. |
| 3. | Abrahamyan L.G., Chatel-Chaix L., Ajamian L, Milev MP, Monette A, Clément JF, Song R., Lehmann M., DesGroseillers L., Laughrea M., Boccaccio G., Mouland A.J.. Novel Staufen1 ribonucleoproteins prevent formation of stress granules but favour encapsidation of HIV-1 genomic RNA. J. Cell Science. 2010. 123(Pt 3):369-83. |
| 4. | Lehmann M., Milev M., Abrahamyan L., Yao X.J., Pante N., Mouland A.J. Intracellular transport of human immunodeficiency virus type 1 genomic RNA and viral production are dependent on dynein motor function and late endosome positioning. J. Biol. Chem. 2009 284: 14572-14585. |
| 5. | Ajamian L.*, Abrahamyan L.*, Milev M., Ivanov P.V., Kulozik A.E., Gehring N.H., Mouland A.J. Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation. RNA. 2008. 14(5):914-27. *Equal contribution. |
| 6. | Ma J., Roy B.B., Zhou Y., Abrahamyan L., Pan Q., Mouland A., and Liang C. Involvement of the DEAD-box protein DDX24 in the Packaging of HIV-1 RNA. Virology. 2008 25;375(1):253-64. |
| 7. | Kafaie J., Song R., Abrahamyan L., Mouland A.J., Laughrea M. Mapping of nucleocapsid residues important for HIV-1 genomic RNA dimerization and packaging. Virology, 2008. 375(2):592-610. |
| 8. | Chatel-Chaix L., Abrahamyan L., Fréchina C., Mouland A., and L. DesGroseillers. The host protein Staufen1 participates in HIV-1 assembly in live cells by influencing pr55Gag multimerization. J. of Virology, 2007, 81(12):6216-30 |
| 9. | Levesque K.*, Halvorsen M.*, Abrahamyan L., Chatel-Chaix L., Gordon H., Desgroseillers L., Gatingnol A., and A.J. Mouland. Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly. Traffic. 2006, vol. 7, No. 9, 1177-93. *Equal contribution. |
| 10. | K.Hu, J-F Clement, Abrahamyan L., Strebel K., Bouvier M., Kleiman L., and A.J. Mouland. A human immunodeficiency virus type 1 protease biosensor assay using bioluminescence resonance energy transfer. J. Virol. Methods. 2005 Sep;128(1-2):93-103. |
| 11. | G.B. Melikyan, R.J.O. Barnard, L.G. Abrahamyan, W. Mothes, and J.A.T. Young. Imaging individual retroviral fusion events: from hemifusion to pore formation and growth. Proc Natl Acad Sci U S A. 2005. 102(24):8728-33 |
| 12. | Abrahamyan L.G., Mkrtchyan S.R, Binley J., Lu M,l., G.B. Melikyan, and F.S. Cohen. The cytoplasmic tail slows the folding of human immunodeficiency virus type 1 Env from a late pre-bundle configuration into the six-helix bundle. Journal of Virology, 2005, vol.79, pp 106-115. |
| 13. | Abrahamyan L.G., Markosyan R.M. , Moore J.P., Cohen F.S. , and Melikyan G.B. Human immunodeficiency virus type 1 env with an intersubunit disulfide bond engages coreceptors but requires bond reduction after engagement to induce fusion. Journal of Virology, 2003, vol.77, No.10, pp 5829-5836. |
| 14. | Abrahamian L.G., Tsymbalyuk E.S., Gazaryan T.G., Levchenko I.V., Andreeva N.B. and K.G. Gazaryan. Expression of Gene for Homoserine Kinase of Escherichia coli in Mammalian Cells. Molecular Biology. Plenum Publishing Corporation, NY, 1996. Vol.30, No.4, p.1, pp 494-498. |
| 15. | Abrahamian L.G., Arkhipova I.R. and N.S. Ambartsumyan. Long terminal repeats of Drosophila mobile elements direct transcription in E.coli cells. Molecular Biology, Plenum Publishing Corporation, NY,1993, V. 27, No 2, p.2, pp. 217-219. |
Education
Doctor of Sci., Institute of Molecular Genetics, Moscow, Russia
Ph.D., Yerevan State University (Armenia) and Virus Genetics Lab, Institute of General Genetics, Moscow, Russia
MSc., Biology/Chemistry, Yerevan State University, Yerevan, Armenia
Professional Positions
Research Assistant professor – University of Nebraska – Lincoln
Nebraska Center for Virology, School of Biological Sciences, 2010-present
Senior Research Scientist – IRCM, Laboratory of Human Retrovirology, Montreal, Quebec, Canada, 2007-2010
Research Scientist - Lady Davis Institute for Medical Research, AIDS Center, McGill University, Montreal, Quebec, Canada, 2004-2007
Instructor/ Research Scientist - Molecular Biophysics & Physiology Department, Rush University Medical Center, Chicago, IL, 2000-2004
Scientist, Assistant Professor -Head of General and Molecular Genetics Laboratory, Industrial University of Santander, Bucaramanga, Colombia, 1997-2000
Scientist, Professor -Head of the Scientific Research Center "Zuncilla", University of Amazonia, Florencia, Caquetá, Colombia, 1995-1997
Doctor of Sci/Professorship courses, Institute of Molecular Genetics, Moscow, Russia, 1994-1995
Research Scientist, Group Leader at Molecular Enzymology Lab, Institute of Molecular Biology, Armenian Academy of Sciences, Yerevan, Armenia, 1990-1994
Professional Affiliations
Nebraska Center for Virology (USA)
American Society for Microbiology (USA)
Canadian Association for HIV Research (Canada)
Armenian Genetics Society (Republic of Armenia)
"Ayas" Sea Explorers Club (Republic of Armenia) - Co-founder
Ornithology Society of Santander (Colombia) - Co-founder
Colombian Genetics Society (Colombia)
Research Interests
Virology, Gene therapy, Cell biology, Host-Pathogen interaction, Antiviral drugs, Drug discovery, Biotechnology