Gustavo A. Delhon , Ph.D.

BSL3 Core Facility Director
School of Veterinary and Biomedical Sciences
University of Nebraska-Lincoln
203 VBS, East Campus
Lincoln, NE 68583-0905
Phone: 402-472-8538
Fax: 402-472-9690
Email: gdelhon3@unlnotes.unl.edu

Professional Positions

Director of the UNL BSL3 Core Facility

Selected Publications

Annamalai, A., Pattnaik, A., Sahoo, B., Muthukrishnan, E., Natarajan, S., Steffen, D., Vu, H., Delhon, G., Osorio, F., Petro, T., Xiang, S-H., and Pattnaik, A. 2017. Zika Virus Encoding Non-Glycosylated Envelope Protein is Attenuated and Defective in Neuroinvasion. J Virol (JVI01348-17R1).

Ponnuraj, N., Khatiwada, S, Chaulagain, S., Delhon, G., and Rock, D.L. 2017. A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-κB signaling. 2017. PLoS Pathogens. 10.1371/journal.ppat.1006779

Khatiwada, S., Delhon, G., Ponnuraj, N., Luo, S., Diel, D.G., Flores, E.F., Rock, D.L. 2017. A parapoxviral virion protein inhibits NF-κB signaling early in infection. Plos Pathogens, PLoS Pathogens. 7;13(8):e1006561. doi: 10.1371/journal.ppat.1006561.

Olson, A., Rico, A., Wang,Z., Delhon, G., and Wiebe, M. 2017. Deletion of the Vaccinia B1 Kinase Reveals Essential Functions of this Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2. J Virol. Jul 12;91(15). pii: e00635-17. doi: 10.1128/JVI.00635-17.

Krishnan, B, Massilamany, C., Basavalingappa, R.H., Gangaplara, A., Kang, G., Li, Q., Uzal, F.A., Strande, J., Delhon, G., Steffen, D., and Reddy, J. 2017. Identification of branched chain α-ketoacid dehydrogenase kinase as a target autoantigen in the induction of cardiac autoimmunity through the generation of autoreactive T cells in A/J mice. Immun Inflamm Dis. Jun 9. doi: 10.1002/iid3.177.

Burmakina, G, Malogolovkin, A., Tulman, E.R., Zsak, L. Delhon, G.,Diel,D.G., Shobogorov, N. Morgunov, Y., Morgunov, S., Kutish, G.F., Kolbasov, D., and Rock, D.L.. 2016. African swine fever virus serotype-specific proteins are significant protective antigens for African swine fever. J. Gen Virol 97:1670-1675.

Huang, T.; Tulman, ER; Diel, DG; Khatiwada, S; Sims, W; Edwards, JF; Wen, X; Kutish, GF; Rock, DL; Delhon, G. 2015. Coinfection with multiple strains of Bovine Papular Stomatitis Virus. Arch. Virol. 160:1527-1532.

Malogolovkin A, Burmakina G, Tulman ER, Delhon G, Diel DG, Salnikov N, Kutish GF, Kolbasov D, Rock DL. 2015. African swine fever virus CD2v and C-type lectin gene loci mediate serologic specificity. J Gen Virol. 96:866-873.

Jia, J., Delhon, G., Tulman, E.R., Diel, D.G., Osorio, F.A., Wen, X., Kutish, G.F., and Rock, D.L. 2014. Novel Gammaherpesvirus Functions Encoded by Bovine herpesvirus 6 (Bovine Lymphotropic virus). J. Gen. Virol. 95: 1790-1798.

Diel, D.G., Luo, S., Delhon, G., Peng, Flores, F., Rock, D.L. 2011. Orf Virus ORFV121 Encodes a Novel Inhibitor of NF-κB that Contributes to Virus Virulence. J. Virol. 85:2037-2049.

Diel, D.G., Luo, S., Delhon, G., Peng, Y., Flores, E., Rock, D.L. 2011. A Nuclear Inhibitor of NF-κB Encoded by a Poxvirus. J. Virol. 85: 264-275.

Diel, D.G.; Delhon, G.; Luo, S., Rock, D.L. 2010. A novel inhibitor of the NF-κB signaling pathway encoded by the parapoxvirus orf virus. J. Virol. 84: 3962-3973.

Tulman, E.; Delhon, G., Ku, B.K.; Rock, D.L. 2009. African swine fever virus. Curr. Top. Microbiol. Immunol. 328:43-87.

Balinsky, C.; Delhon, G., Smoliga, G., Prarat, M., French, R.A., Geary, S.J., Rock, D.L., Rodriguez, L.L. 2008. Rapid preclinical detection of sheeppox virus by a Real-Time PCR assay. J. Clin. Microb. 46:438-442.

Balinsky, C.; Delhon, G., Afonso, C., Risatti,G.R., Borca, M.V., French, R.A., Tulman, E.R., Rock, D.L. 2007. Sheepox virus kelch-like gene SPPV-019 affects virus virulence. J. Virol. 81:11392-11401.

Tulman,E.R., Delhon, G., Afonso, C.L., Lu, Z., Zsack, L., Sandybaev, N.T., Kerembekova, U.Z., Zaitsev, V. L., Kutish, G.F., Rock, D.L. 2006. Genome of horsepox virus. J. Virol. 80: 9244-9258.

Delhon, G., Tulman, E. R., Afonso, C. L., Lu, Z., Becnel, J.J., Moser, B. A., Kutish, G. F., Rock, D.L. 2006. Genome of Invertebrate iridescent virus type 3 (mosquito iridescent virus). J. Virol. 80: 8439-8449.

Carrillo, C., Tulman, E. R., Delhon, G., Lu, Z., Carreno, A., Vagnozzi, A., Kutish, G.F., Rock, D.L. 2005. Comparative genomics of foot-and-mouth disease virus. J. Virol. 79:6487-6504.

Delhon, G., Tulman, E., Afonso, C., Lu, Z., de la Concha-Bermejillo, A., Lehmkuhl, H.D., Piccone, M.E., Kutish, G. F., Rock, D.L. 2004. Genomes of parapoxviruses Orf virus and Bovine papular stomatitis virus. J. Virol. 78:168-177.

Delhon, G., Moraes, M.P., Lu, Z., Afonso, C.L., Flores, E.F., Weiblen, R., Kutish, G.F., and Rock, D.L.2003. The genome of bovine herpesvirus type 5. J. Virol. 77:10339-10347.

Education

DVM: University of Buenos Aires, 1980.

Research Fellowship, National Council for Scientific and Technical Research, Buenos Aires, 1981.

MSc.: University of Nebraska-Lincoln (Major: Virology; Veterninary Sc.), 1990.

PhD: University of Nebraska Medical Center (Major: Virology; Veterninary Sc.), 1996.

MSc in Tertiary Education, University of Buenos Aires, 1998.

Research Interests

Research focuses on poxviral infections, including functional genomics of animal poxviruses and pathogenesis of orf (a worldwide poxviral disease of sheep) and sheeppox (an exotic disease of sheep that shares important clinical and epidemiological features with smallpox).

Studies will determine the roles in disease of a unique set of orf virus genes potentially involved in virus virulence and host-range.