For Yue Tso
University of Nebraska-Lincoln
Advisor: Dr. Wood
PhD THESIS DEFENSE
“Evolution of Human Immunodeficiency Virus Type 1 Clade C Envelop V1-V5 region during Disease Progression in Non- Human Primate Model” " The highly variable nature of the HIV-1 envelope gene and the absence of a suitable animal model are some of the obstacles towards developing an effective anti-HIV-1 vaccine. Strengthening of the understanding of envelope evolution during disease progression will contribute significantly towards future anti-HIV-1 treatment and preventions. To address this issue, we first demonstrated that the infection of non-human primates with a simian-human immunodeficiency virus (SHIV) expressing the HIV-1 clade C V1-V5 envelope regions from Zambia is a good model for HIV-1 research. Using this model, we analyzed the genetic evolution and biological characteristic variations of the HIV-1 V1-V5 envelope regions through disease progression. Our results underscore the dynamic evolutionary relationships between the intrinsic properties of the HIV-1 envelopes, their evolution and host immune response. Findings from this study may contribute to the eventual resolution of the AIDS pandemic and our knowledge of the roles that HIV-1 envelope plays during disease progression." For Yue Tso University of Nebraska-Lincoln Advisor: Dr. Wood Tuesday April 9, 2013 9:00 a.m. 145 Morrison Center In Partial Fulfillment of Requirements for the Ph.D. Degree The University of Nebraska-Lincoln is an equal opportunity educator and employer with a comprehensive plan for diversity.