The Redox Biology Center
Summer REU Training Program at the University of Nebraska-Lincoln was established in 2006 by the National Science Foundation
to carry out independent research projects in redox biochemistry. Research areas range from molecular medicine to environmental biochemistry and plant biochemistry.
REU students participate in exciting projects at the cutting edge of research in redox biology. They formulate and test hypotheses, develop experimental problem-solving skills, and receive training in biochemical, biophysical and molecular biology techniques. Students are also exposed to a variety of instrumentation such as HPLC and FPLC systems, EPR spectroscopy, mass spectroscopy and microscopy which are located in the interdisciplinary Beadle Center
Individual projects are designed to be completed within the ten-week time frame of the summer program. The projects generally fit into the larger context of the faculty advisor's research program.
Students are placed with a faculty mentor in whose lab the student's research project will be pursued and students are expected to participate fully in the life of the mentor's lab. There are informal meetings for all program participants which facilitate the exchange of information on the research being conducted. There are also weekly meetings in which various scientists describe the latest advances in their own research or career opportunities in biomedical or biotechnology fields. These events provide an opportunity to discuss areas of biochemistry/redox biology that are of particular interest and excitement.
The ten-week summer program is sponsored by the National Science Foundation
and Department of Defense
Proteomics and metabolomics approaches to identify specific molecular pathways of cellular response to various forms of stress.
Pathogenic strategies employed by bacteria to cause plant diseases focusing on the type III protein secretion system and the bacterial virulence proteins it injects into host cells.
Joseph J. Barycki, Ph.D.
Glutathione is the major cellular antioxidant and affords protection against reactive oxygen and nitrogen species. Disruption of glutathione homeostasis has been implicated in neurodegenerative diseases, cancer, diabetes mellitus, atherosclerosis, and rheumatoid arthritis. Our lab studies how glutathione is synthesized and degraded at the molecular, cellular, and organismal level.
Donald F. Becker, Ph.D.
Redox regulatory mechanisms, protein structure-function relationships and proline metabolism.
Biological methane production, redox biochemistry, microbial physiology.
Rodrigo Franco Cruz, Ph.D.
Veterinary and Biomedical Sciences
Oxidative stress and neuronal cell death in neurodegenerative diseases.
Biochemistry, chemistry and biosynthesis of antibiotics and mycotoxins.
Redox biology, bioinformatics, transcription regulation and molecular diagnostic systems.
Mitochondrial Homeostasis: Biogenesis of Redox-Active Compounds and Mechanisms of Quality Control and Protection.
Mechanisms of metal-ion metabolism, copper transporters and oxidative stress response.
Develop NMR and bioinformatic methodologies to explore the structure, function, and evolution of proteins to aid in the discovery of new drugs.
Jay Reddy, Ph.D.
Veterinary and Biomedical Sciences
Cellular and molecular mechanisms underlying the development of human autoimmune diseases.
Prostate cancer, early regulation of tumor formation and extracellular control of gene expression.
Veterinary Medicine and Biomedical Sciences
Elucidation of mechanisms by which Staphylococcus aureus controls virulence factor production in response to nutrient limitation.
Julie M. Stone, Ph.D.
Molecular mechanisms and regulation of programmed cell death (PCD) in plants, the role of PCD in plant development and response to pathogens and signal transduction.
Structural biology of proteins involved in neurodegenerative diseases.