Proteomics and metabolomics approaches to identify specific molecular pathways of cellular response to various forms of stress.
Pathogenic strategies employed by bacteria to cause plant diseases focusing on the type III protein secretion system and the bacterial virulence proteins it injects into host cells.
Joseph J. Barycki, Ph.D. Biochemistry
Glutathione is the major cellular antioxidant and affords protection against reactive oxygen and nitrogen species. Disruption of glutathione homeostasis has been implicated in neurodegenerative diseases, cancer, diabetes mellitus, atherosclerosis, and rheumatoid arthritis. Our lab studies how glutathione is synthesized and degraded at the molecular, cellular, and organismal level.
Donald F. Becker, Ph.D. Biochemistry
Redox regulatory mechanisms, protein structure-function relationships and proline metabolism.
Biological methane production, redox biochemistry, microbial physiology.
Rodrigo Franco Cruz, Ph.D. Veterinary and Biomedical Sciences
Oxidative stress and neuronal cell death in neurodegenerative diseases.
Biochemistry, chemistry and biosynthesis of antibiotics and mycotoxins.
Mitochondrial Homeostasis: Biogenesis of Redox-Active Compounds and Mechanisms of Quality Control and Protection.
Mechanisms of metal-ion metabolism, copper transporters and oxidative stress response.
Develop NMR and bioinformatic methodologies to explore the structure, function, and evolution of proteins to aid in the discovery of new drugs.
Jay Reddy, Ph.D. Veterinary and Biomedical Sciences
Cellular and molecular mechanisms underlying the development of human autoimmune diseases.
Prostate cancer, early regulation of tumor formation and extracellular control of gene expression.
Elucidation of mechanisms by which Staphylococcus aureus controls virulence factor production in response to nutrient limitation.
Julie M. Stone, Ph.D. Biochemistry
Molecular mechanisms and regulation of programmed cell death (PCD) in plants, the role of PCD in plant development and response to pathogens and signal transduction.
Structural biology of proteins involved in neurodegenerative diseases.