Our research program addresses pathogenic and therapeutic questions of some the most devastating viral and neuroimmune disorders facing the global community including molecular, epidemiological, and biochemical approaches to address fundamental questions concerning viral replication, latency, assembly and pathogenesis. These projects include the investigation of mechanisms of HIV replication and pathogenesis; and neurodegenerative diseases such as Alzheimer's disease, prion diseases and HIV-1-associated dementia. Other projects involve chronic and latent infections caused by viruses such as herpes simplex, Epstein-Barr and Kaposi's Sarcoma associated herpesvirus. Investigators are also studying viral host interactions including the mechanism of viral induced cellular transformation
| Mechanisms that control stable replication of human papillomaviruses (HPVs) | Peter C. Angeletti, PhD |
| Prion Targeting | Jason C. Bartz, PhD |
| Development of cytolytic CD4 T cell responses through vaccination or viral infection | Deborah M. Brown, Ph.D. |
| Protein Structure and Function, Proteomics | Pawel Ciborowski, PhD |
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HIV Neuropathogenesis |
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| Evaluating different immunization strategies using adjuvants and antibody immunotherapies to enhance protective immune responses induced by HIV vaccine candidates. | Santhi Gorantla, PhD |
| Prion Entry into the Nervous System | Anthony E. Kincaid, PhD |
| RNA Virus Gene Expression | Asit K. Pattnaik, PhD |
| IL-12 expression during innate anti-viral immunity against Theiler's Virus infection | Thomas M. Petro, PhD |
| Murine model of HIV-1encephalitis in NOD/SCID mice reconstituted with human lymphocytes | Larisa Poluektova, MD, PhD |
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Chlorella Viruses Biology |
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HIV and Herpes Virus Pathogenesis |
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HIV Neurophysiology |
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Herpes Viral Latency and Interferon Regulatory Factors |
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Chemokines and HIV Dementia |
