Current Research

Our research program addresses pathogenic and therapeutic questions of some the most devastating viral and neuroimmune disorders facing the global community including molecular, epidemiological, and biochemical approaches to address fundamental questions concerning viral replication, latency, assembly and pathogenesis. These projects include the investigation of mechanisms of HIV replication and pathogenesis; and neurodegenerative diseases such as Alzheimer's disease, prion diseases and HIV-1-associated dementia. Other projects involve chronic and latent infections caused by viruses such as herpes simplex, Epstein-Barr and Kaposi's Sarcoma associated herpesvirus. Investigators are also studying viral host interactions including the mechanism of viral induced cellular transformation

Mechanisms that control stable replication of human papillomaviruses (HPVs) Peter C. Angeletti, PhD
Prion Targeting Jason C. Bartz, PhD
Development of cytolytic CD4 T cell responses through vaccination or viral infection Deborah M. Brown, Ph.D.
Protein Structure and Function, Proteomics Pawel Ciborowski, PhD

HIV Neuropathogenesis

Howard Gendelman, MD

Evaluating different immunization strategies using adjuvants and antibody immunotherapies to enhance protective immune responses induced by HIV vaccine candidates. Santhi Gorantla, PhD
Prion Entry into the Nervous System Anthony E. Kincaid, PhD
RNA Virus Replication and Pathogenesis Asit K. Pattnaik, PhD
IL-12 expression during innate anti-viral immunity against Theiler's Virus infection Thomas M. Petro, PhD
Murine model of HIV-1encephalitis in NOD/SCID mice reconstituted with human lymphocytes Larisa Poluektova, MD, PhD

Chlorella Viruses Biology

James Van Etten, PhD

HIV and Herpes Virus Pathogenesis

Charles Wood, PhD

HIV Neurophysiology

Huangui Xiong, MD, PhD

Herpes Viral Latency and Interferon Regulatory Factors

Luwen Zhang, PhD

Chemokines and HIV Dementia

Jialin Zheng, MD