You (Joe) Zhou, PhD

Research Professor
University of Nebraska-Lincoln
Center for Biotechnology
E117 Beadle Center
Lincoln, NE 68588-0665
Phone - 402.472.5935 (Office), 5942 (Lab)
Fax - 402.472.3139

Research Projects (ongoing)

  1. Advanced bioimaging technology: confocal microscopy for immunofluorescence or live cell imaging analysis and electron microscopy.

  2. Search for biomarkers of altered stress response/adaptation using animal models.

Selected Recent Publications

  1. Chowdhury, S.I., P.S. Bhattachajee, A. Al-Mubarak, M.L. Weiss, M. Onderci, and Y. Zhou. 2002. Bovine herpesvirus 5 (BHV-5) us9 is essential for BHV-5 neuropathogenesis. J. Virol. 76(8):3839-51.
  2. Dasgupta S., Y. Zhou, M. Jana, N.L. Banik and K. Pahan. 2003.  Sodium phenylacetate inhibits the adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps.  J. Immunol. 170(7):3874-82.
  3. Ryan, L., Peng, H., Erichsen, D., Huang, Y., Persidsky, Y. Zhou, H.E.  Gendelman, and J. Zheng. 2004. Links between tumor necrosis factor related apoptosis Inducing Ligand Mediated Human Neuronal Apoptosis and HIV-1 Associated Dementia. J. Neuroimmunol. 148: 127-139.
  4. Dasgupta S, M. Jana M, Y. Zhou, Y.K. Fung, S. Ghosh, K.  Pahan. 2004 Antineuro-inflammatory effect of NF-kappa-B essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis. J. Immunol. 173(2):1344-54.
  5. Zhang L, Zhang J, Lambert Q, Der CJ, Del Valle L, Miklossy J, Khalili K, Zhou Y, Pagano JS. 2004 Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties. J Virol. 78(23):12987-95.
  6. Su D, Novoselov SV, Sun QA, Moustafa ME, Zhou Y, Oko R, Hatfield DL, Gladyshev VN. 2005. Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. J. Biol Chem. 280(28):26491-8.
  7. Boehm, M.B., T.J. Milius, Y.  Zhou, J. J. Westendorf, S. Koka, 2005. The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway. Biochem. Biophys. Res. Commun. 335(4):1090-4.
  8. Chowdhury, S.I.  Al-Mubarak, A., Y. Zhou. 2006. The Us9 gene of bovine herpesvirus 1 (BHV-1) effectively complements a Us9-null strain of BHV-5 for anterograde transport, neurovirulence, and neuroinvasiveness in a rabbit model.  J. Virol. 80:4396-405.
  9. Das, S.C., D. Nayak, Y. Zhou, and A. K. Pattnaik.  2006.  Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells.  J. Virol. 80: 6368-6377.
  10. Perez S, Lovato L, Zhou J(Y), Doster A, Jones C. 2006. Comparison of inflammatory infiltrates in trigeminal ganglia of cattle infected with wild-type Bovine herpesvirus 1 versus a virus strain containing a mutation in the LR (latency-related) gene.  J Neurovirol. 2006 Oct;12(5):392-7.
  11. LaRosa, P.C., J. Miner, Y. Xia, Y. Zhou, S. Kachman and M. E. Fromm.  2006 Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis. Physiol. Genomics Nov 27;27(3):282-94.
  12. Kabil, O., Y. Zhou and R. Banerjee. 2006. Human cystathionine β-synthase is a target for sumoylation.  Biochem. Nov 14;45(45):13528-36
  13. Xu, D. A. Buehner, J. Xu, T. Lambert, C. Nekl, M.K. Nielsen, Y. Zhou. 2006. A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviors.  FASEB J Nov 20(13): E1802–E1810.
  14. Dou, H., J. Morehead,  C. J. Destache, J. Limoges, B. Ellison, J. D. Kingsley, L.  Shlyakhtenko, Y. Zhou, M. Chaubal,  J.  Werling,  J. Kipp,  B. Rabinow, and H. E. Gendelman. 2007. Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages.  Virol. 358(1):148-58.
  15. Saira K, Y. Zhou, C. Jones 2007. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) induces degradation of interferon response factor 3 (IRF3), and consequently inhibits beta interferon promoter activity. J. Virol. 81(7):3077-86.
  16. Chen, K.C, Y. Zhou, W. Zhang, M.F. Lou. 2007. Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells.  Mol  Vis. 13:374-87.
  17. Meyer F, Perez S, Jiang Y, Zhou Y, Henderson G, Jones C. 2007. Identification of a novel protein encoded by the latency-related gene of bovine herpesvirus 1. J Neurovirol. 2007 Dec;13(6):569-78
  18. Zhang, Y., Y. Zhou, U. Schweizer, N. E. Savaskan, D. Hua, J. Kipnis, D. L. Hatfield, V. N. Gladyshev 2008. Comparative analysis of selenocysteine machinery and selenoprotein gene expression in mouse brain identifies key brain areas dependent on selenium.  J. Biol. Chem.283: 2427-38.
  19. Peng H, Whitney N, Wu Y, Tian C, Dou H, Zhou Y, Zheng J. 2008. HIV-1-infected and/or immune-activated macrophage-secreted TNF-alpha affects human fetal cortical neural progenitor cell proliferation and differentiation. Glia. 2008 Jun; 56(8):903-16.
  20. Saira K, Zhou Y, Jones C. 2009.  The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 (IRF7), and consequently inhibits beta interferon promoter activity. J Virol. 2009 Apr;83 (8):3977-81.
  21. Wen HJ, Yang Z, Zhou Y, Wood C. 2010 Enhancement of autophagy during lytic replication by the Kaposi's sarcoma-associated herpesvirus replication and transcription activator. J Virol. 2010 Aug; 84(15):7448-58. 
  22. Malinouski, M., Y. Zhou, V.V. Belousov, D.L. Hatfield, V.N. Gladyshev, 2011.  Hydrogen peroxide probes directed to different cellular compartments.  PLoS One. 2011 Jan 21; 6(1):e14564. 
  23. Chen, Z.G., Z.P. Xu, M. Zhang, Y. Zhou, M. Liu, T. Patten, G.Y. Liu, H. Li, X.C. Zeng, L. Tan,  2012.  "Two-Dimensional Crystallization of Hexagonal Bilayer with Moiré Patterns".   J.  Phys. Chem. B:  2012 Apr 12;116(14):4363-9. Epub 2012 Mar 14 (PMID:22356348)
  24. Wu Y, Chen Q, Peng H, Dou H, Zhou Y, Huang Y, Zheng JC. 2012. Directed migration of human neural progenitor cells to interleukin-1β is promoted by chemokines stromal cell-derived factor-1 and monocyte chemotactic factor-1 in mouse brains. Transl Neurodegener. 2012 Jul 31;1(1):15.
  25. Valente RM, Ehlers E, Xu D, Ahmad H, Steadman A, Blasnitz L, Zhou Y, Kastanek L, Meng B, Zhang L. 2012 Toll-like receptor 7 stimulates the expression of epstein-barr virus latent membrane protein 1. PLoS One. 2012; 7(8): e43317. Epub 2012 Aug 31
  26. Shibata A, McMullen E, Pham A, Belshan M, Sanford B, Zhou Y, Goede M, Date AA, Destache C. 2013. Polymeric nanoparticles containing combination antiretroviral drugs for HIV-1 treatment. AIDS Res Hum Retroviruses. 2013 May; 29(5):746-54.
  27. Rodriguez-Rocha H, Garcia-Garcia A, Pickett C, Sumin L, Jones J, Chen H, Webb B, Choi J, Zhou Y, Zimmerman MC, Franco R. 2013. Compartmentalized oxidative stress in dopaminergic cell death induced by pesticides and complex I inhibitors: Distinct roles of superoxide anion and superoxide dismutases.  Free Radic Biol Med. 2013 Apr 19. pii: S0891-5849(13)00161-5. 2013.04.021. (Epub ahead of print).
  28. Wang G, Xu Z, Chen Z, Niu W, Zhou Y, Guo J, Tan L. 2013. Sequential binding of large molecules to hairy MOFs. Chem Commun (Camb). 2013 Jun 27;49(59):6641-3. doi: 10.1039/c3cc42711k.


Professional Positions

May 2009-Present Professor (Research), Center for Biotechnology and Veterinary & Biomedical Sciences, University of Nebraska-Lincoln

Associate Professor (Res.), Center for Biotechnology andDept. of Veterinary & Biomedical Sci. UNL

Res. Assistant Professor, Center for Biotechnology and Veterinary & BiomedicalSci. UNL

Instructor- Pennington Biomedical Research Center
Louisiana State University